Real-time qPCR Reagent Kit for quantification of the mutant allele Val617Phe in the JAK2 gene SMuQ

Real-time qPCR Reagent Kit for quantification of the mutant allele Val617Phe in the JAK2 gene SMuQ

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Information

Sets of reagents in the SMuQ (Somatic Mutations Quantitative) format are designed for the quantitative determination of somatic mutations in human genes by allele- specific PCR with real-time detection. Scope of application: in oncogematology in the differential diagnosis of Ph-negative myeloprophilerative diseases (true polycythemia, essential thrombocytemia, primary myelofibrosis). The specific determination of the mutant allele is achieved due to the different effectiveness of Taq polymerase elongation completely and incompletely of the complementary primer target, as well as selective blocking of amplification of the wild-type allele.

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